לרשותכם אינדקס מאמרים ומחקרים קליניים אשר נערכו בנושא ויטמין C והשפעותיו על מערכות הגוף השונות.
למעבר למאמר לחצו על הקישור:
ויטמין C וכלי דם:
Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials.
Br J Nutr. 2015 Apr ;113(8):1182-94. PMID: 25919436
Antioxidant vitamin C prevents decline in endothelial function during sitting.
Med Sci Monit. 2015 ;21:1015-21. Epub 2015 Apr 7. PMID: 25848890
Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
Circulation. 1996 Mar 15;93(6):1107-13. PMID: 8653830
Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
Circulation. 1999 Jun 29;99(25):3234-40. PMID: 10385496
Effects of vitamin supplementation on microcirculatory disturbance in hemodialysis patients without peripheral arterial disease.
Clin Nephrol. 2003 Jul;60(1):28-34. PMID: 12872855
ויטמין C וסרטן:
Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects.
Free Radic Biol Med. 2009 Jul 1;47(1):32-40. Epub 2009 Feb 28. PMID: 19254759
Radioprotective and Apoptotic Properties of a Combination ofα-Tocopherol Acetate and Ascorbic Acid.
Bull Exp Biol Med. 2016 Jul 7. Epub 2016 Jul 7. PMID: 27383172
In vitro and in vivo assessment of high-dose vitamin C against murine tumors.
Exp Ther Med. 2016 Nov ;12(5):3058-3062. Epub 2016 Sep 16. PMID: 27882116
Molecular mechanisms of pharmacological doses of ascorbate on cancer cells.
Wien Med Wochenschr. 2015 Jun ;165(11-12):251-7. Epub 2015 Jun 12. PMID: 26065536
Oncotarget. 2017 Sep 15 ;8(40):67269-67286. Epub 2017 Jun 9. PMID: 28978032
Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells.
Biochem Biophys Res Commun. 2018 02 26 ;497(1):347-353. Epub 2018 Feb 9. PMID: 29432735
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine.
Proc Natl Acad Sci U S A. 2016 09 13 ;113(37):10238-44. Epub 2016 Aug 29. PMID: 27573823
ויטמין C ונזקי DNA:
Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress.
J Oral Sci. 2010;52(2):251-6. PMID: 20587949
High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots.
Am J Clin Nutr. 2009 Nov;90(5):1402-10. Epub 2009 Sep 30. PMID: 19793852
Vitamin E and vitamin C supplementation in patients with chronic obstructive pulmonary disease.
Int J Vitam Nutr Res. 2007 Jul;77(4):272-9. PMID: 18271282
ויטמין C וסוכרת:
Effect of ascorbic acid and alpha-tocopherol supplementations on serum leptin, tumor necrosis factor alpha, and serum amyloid A levels in individuals with type 2 diabetes mellitus.
Avicenna J Phytomed. 2015 Nov-Dec;5(6):531-9. PMID: 26693410
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children.
Diabet Med. 2015 Oct 24. Epub 2015 Oct 24. PMID: 26498636
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study.
Free Radic Biol Med. 2016 Jan 13. Epub 2016 Jan 13. PMID: 26774673
ויטמין C והריון:
Vitamin C and the risk of gestational diabetes mellitus: a case-control study.
Ann Surg. 1998 Apr;227(4):485-91. PMID: 15134150
Reduced Collagen and Ascorbic Acid Concentrations and Increased Proteolytic Susceptibility with Prelabor Fetal Membrane Rupture in Women
Emma L. Stuart Gareth S. Evans Yu Shan Lin Hilary J. Powers
Biology of Reproduction, Volume 72, Issue 1, 1 January 2005
Endometriosis and deficient intake of antioxidants molecules related to peripheral and peritoneal oxidative stress.
Ginecol Obstet Mex. 2006 Jan;74(1):20-8. PMID: 16634350
Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis.
Int J Gynaecol Obstet. 2008 Mar;100(3):252-6. Epub 2007 Nov 19. PMID: 18005966
Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet.
Cancer Res. 2005 Sep 1;65(17):8049-56. PMID: 19476631
Targeting oxidative stress to treat endometriosis.
Expert Opin Ther Targets. 2015 Aug 10:1-18. Epub 2015 Aug 10. PMID: 26256952
ויטמין C והשמנה:
Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress.
Redox Biol. 2015 Jun 26 ;6:206-217. Epub 2015 Jun 26. PMID: 26262997
Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial.
Drug Des Devel Ther. 2015 ;9:3405-12. Epub 2015 Jul 1. PMID: 26170625
Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration.
Thorax. 2008 Jan;63(1):21-6. Epub 2007 Jun 15. PMID: 17573441
ויטמין C וספיגת ברזל:
Plasma vitamin C levels in ESRD patients and occurrence of hypochromic erythrocytes.
Hemodial Int. 2016 Sep 12. Epub 2016 Aug 12. PMID: 27619554
ויטמין C וטיפול בדלקות:
An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
Am J Clin Nutr. 2010 Apr;91(4):1044-59. Epub 2010 Feb 24. PMID: 20181810
Consumption of high-pressurized vegetable soup increases plasma vitamin C and decreases oxidative stress and inflammatory biomarkers in healthy humans.
J Nutr. 2004 Nov ;134(11):3021-5. PMID: 15514269
Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis.
Circulation. 2001 Apr 10;103(14):1863-8. PMID: 11294804
Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial.
Drug Des Devel Ther. 2015 ;9:3405-12. Epub 2015 Jul 1. PMID: 26170625
ויטמין C ועישון:
Acute effect of oral vitamin C on coronary circulation in young healthy smokers.
Am Heart J. 2004 Aug;148(2):300-5. PMID: 15309000
Vitamin C Prevents Offspring DNA Methylation Changes Associated with Maternal Smoking in Pregnancy.
Am J Respir Crit Care Med. 2017 Apr 19. Epub 2017 Apr 19. PMID: 28422514
Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma.
J Perinatol. 2018 May 22. Epub 2018 May 22. PMID: 29785060
ויטמין C ואסטמה:
Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study.
Acta Paediatr. 2009 Apr;98(4):737-42. Epub 2008 Jan 11. PMID: 19154523
Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen.
Phytother Res. 2011 Jan;25(1):128-36. PMID: 20632299
ויטמין C למערכת החיסון:
High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice.
Br J Nutr. 2015 Feb 28 ;113(4):603-9. Epub 2015 Jan 22. PMID: 25608928
The epigenetic role of vitamin C in health and disease.
Cell Mol Life Sci. 2016 Apr ;73(8):1645-58. Epub 2016 Aug 4. PMID: 26846695
Antiviral effects of ascorbic and dehydroascorbic acids in vitro.
Int J Mol Med. 2008 Oct;22(4):541-5. PMID: 18813862
The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis.
Nutrients. 2018 Mar 16 ;10(3). Epub 2018 Mar 16. PMID: 29547516
ויטמין C ובריאות העין והראייה:
Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
Arch Ophthalmol. 2008 Jan;126(1):102-9. PMID: 18195226
Prevention of selenite cataract by vitamin C
Author links open overlay panelP.S.DevamanoharanM.HeneinS.MorrisS.RamachandranR.D.RichardsS.D.Varma
The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts.
Arch Ophthalmol. 2009 Apr;127(4):475-82. PMID: 19365028
Strategies to reduce oxidative stress in glaucoma patients.
Curr Neuropharmacol. 2017 07 5. Epub 2017 Jul 5. PMID: 28677495
ויטמין C ונזקים חמצוניים:
Vitamin C prevents memory impairment induced by waterpipe smoke: role of oxidative stress.
Inhal Toxicol. 2018 May 22:1-8. Epub 2018 May 22. PMID: 29788804
ויטמין C ואנטי אייג’ינג:
Effect of a novel dietary supplement on skin aging in post-menopausal women.
Eur J Clin Nutr. 2006 Oct;60(10):1201-6. Epub 2006 May 3. PMID: 16670692
Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin.
J Cosmet Dermatol. 2008 Dec ;7(4):290-7. PMID: 19146606
Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors.
Gastroenterol Hepatol. 1997 Apr;20(4):172-4. PMID: 17028931
Longitudinal associations between micronutrient consumption and leukocyte telomere length.
J Hum Nutr Diet. 2016 Aug 22. Epub 2016 Aug 22. PMID: 27550625
ויטמין C והרעלת אלכוהול:
Effect of ascorbic acid on plasma alcohol clearance.
J Am Coll Nutr. 1990 Jun;9(3):185-9. PMID: 2358613
Co-Treatment with Anthocyanins and Vitamin C Ameliorates Ethanol- Induced Neurodegeneration via Modulation of GABAB Receptor Signaling in the Adult Rat Brain.
CNS Neurol Disord Drug Targets. 2015 ;14(6):791-803. PMID: 25714970
ויטמין C והליקובקטור פילורי:
Oxidative stress in Helicobacter pylori infection: does supplementation with vitamins C and E increase the eradication rate?
Helicobacter. 2009 Aug;14(4):280-5. PMID: 19674132
Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice.
Antimicrob Agents Chemother. 2000 Sep;44(9):2452-7. PMID: 10952594
Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication.
Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 17419283
ויטמין C וסטרס:
A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.
Psychopharmacology (Berl). 2002 Jan;159(3):319-24. Epub 2001 Nov 20. PMID: 11862365
Melatonin is more effective than ascorbic acid andβ-carotene in improvement of gastric mucosal damage induced by intensive stress.
Arch Med Sci. 2015 Oct 12 ;11(5):1129-36. PMID: 26528359
ויטמין C ואיחוי שברים בעצמות:
The effect of zymosan and the protective effect of various antioxidants on fracture healing in rats.
Arch Orthop Trauma Surg. 2007 Sep;127(7):493-501. Epub 2007 Jul 17. PMID: 17639432
ויטמין C ואלצהיימר:
Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID: 21103342
Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease.
J Mol Neurosci. 2016 Sep 24. Epub 2016 Sep 24. PMID: 27665568
Preventive and Therapeutic Potential of Vitamin C in Mental Disorders.
Curr Med Sci. 2018 Feb ;38(1):1-10. Epub 2018 Mar 15. PMID: 30074145
Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease.
Mol Chem Neuropathol. 1998 Feb;33(2):139-48. PMID: 9565971
Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases.
|Zh Nevrol Psikhiatr Im S S Korsakova. 2017 ;117(7):112-119. PMID: 28805771
ויטמין C והספקטרום האוטיסטי:
Oxidative stress in autism.
Altern Ther Health Med. 2004 Nov-Dec;10(6):22-36; quiz 37, 92. PMID: 15624347
A preliminary trial of ascorbic acid as supplemental therapy for autism.
Prog Neuropsychopharmacol Biol Psychiatry. 1993 Sep;17(5):765-74. PMID: 8255984
Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder.
J Altern Complement Med. 2004 Dec;10(6):1033-9. PMID: 15673999
ויטמין C ושיפור ביצועים ספורטיביים:
Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running.
Int J Sports Med. 2001 Oct;22(7):537-43. PMID: 11590482
Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners.
Int J Sports Med. 2001 Feb;22(2):120-6. PMID: 11281614
ויטמין C ומחלות של מערכת העיכול:
Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate sodium-induced ulcerative colitis in mice.
Int J Clin Exp Med. 2015 ;8(11):20245-53. Epub 2015 Nov 15. PMID: 26884937
High-dose ascorbate with low-dose amphotericin B attenuates severity of disease in a model of the reappearance of candidemia during sepsis in the mouse.
Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1 ;309(3):R223-34. PMID: 25994956
ויטמין C ומיגרנות:
Vitamin Supplementation as Possible Prophylactic Treatment against Migraine with Aura and Menstrual Migraine.
Biomed Res Int. 2015;2015:469529. Epub 2015 Feb 28. PMID: 25815319
ויטמין C והרעלת מתכות:
Role of ascorbic acid supplement in amelioration of anaemia in lead intoxication.
J Pak Med Assoc. 2016 Sep ;66(9):1073-1076. PMID: 27654722
Ascorbic Acid Ameliorates Gestational Lead Exposure-Induced Developmental Alteration in GAD67 and c-Kit Expression in the Rat Cerebellar Cortex.
Biol Trace Elem Res. 2017 Jul 6. Epub 2017 Jul 6. PMID: 28685241
ויטמין C ובלוטת התריס:
Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin C supplementation.
Clin Chem Lab Med. 1998 Oct;36(10):767-70. PMID: 9853803
Beneficial role of ascorbic and folic acids antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats.
Environ Sci Pollut Res Int. 2016 May 25. Epub 2016 May 25. PMID: 27221465
Effects of vitamin E and vitamin C supplementation on plasma lipid peroxidation and on oxidation of apolipoprotein B-containing lipoproteins in experimental hyperthyroidism.
J Med Invest. 1999 Feb;46(1-2):29-33. PMID: 10408154
ויטמין C ורעלים סביבתיים:
Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection.
PLoS One. 2015 ;10(8):e0131097. Epub 2015 Aug 13. PMID: 26270818
Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study.
Oncotarget. 2016 Nov 25. Epub 2016 Nov 25. PMID: 27901495
The protective effect of vitamins C and E against B(a)P-induced genotoxicity in human lymphocytes.
J Environ Pathol Toxicol Oncol. 1999;18(3):159-67. PMID: 15281228
ויטמין C ודימנציה:
Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017 ;117(7):112-119. PMID: 28805771
ויטמין C ופרקינסון:
Ascorbate- and zinc-responsive parkinsonism.
Ann Pharmacother. 2014 Nov ;48(11):1515-20. Epub 2014 Jul 28. PMID: 25070397
Restorative potential of dopaminergic grafts in presence of antioxidants in rat model of Parkinson’s disease.
J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID: 15531136
Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner.
Stem Cells. 2015 Apr ;33(4):1320-32. PMID: 25535150
Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson’s Disease.
Stem Cell Reports. 2017 Sep 18. Epub 2017 Sep 18. PMID: 28943252
ויטמין C והפרעות שינה:
Relief from cancer chemotherapy side effects with pharmacologic vitamin C.
N Z Med J. 2014 Jan 24 ;127(1388):66-70. Epub 2014 Jan 24. PMID: 24481389
ויטמין C ופגיעה בעמוד השדרה:
Protective effects of Vitamin C against spinal cord injury-induced renal damage through suppression of NF-κB and proinflammatory cytokines.
Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID: 25403314
ויטמין C וטיפול בכוויות:
The role of topically applied l-ascorbic acid in ex-vivo examination of burn-injured human skin.
Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 30 ;185:279-285. Epub 2017 May 30. PMID: 28591686
ויטמין C וחוסר איזון הורמונלי:
Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences.
Radiat Phys Chem Oxf Engl 1993. Updated 2011 Aug ;80(8):890-894. PMID: 21814301
ויטמין C ומחלות פסיכיאטריות:
Ascorbic Acid to Manage Psychiatric Disorders.
CNS Drugs. 2017 Jun 9. Epub 2017 Jun 9. PMID: 28600627
ויטמין C וזיהומים:
Vitamin C and Infections.
Nutrients. 2017 Mar 29 ;9(4). Epub 2017 Mar 29. PMID: 28353648
ויטמין C וריפוי פצעים:
Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies.
Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):588-95. PMID: 19770648
High dose oral vitamin C and mesenchymal stem cells aid wound healing in a diabetic mouse model.
J Wound Care. 2018 May 2 ;27(5):334-339. PMID: 29738298
